P-53 Outcome of preimplantation genetic diagnosis of balanced translocation carriers
نویسندگان
چکیده
منابع مشابه
Outcome of preimplantation genetic diagnosis of translocations.
OBJECTIVE To review 35 cases of preimplantation genetic diagnosis (PGD) of translocations with several methods, including telomeric probes. DESIGN Retrospective study. SETTING Clinical IVF laboratory. PATIENT(S) Thirty-five couples with one partner carrying a chromosomal translocation. INTERVENTION(S) PGD of translocation after polar-body or embryo biopsy. MAIN OUTCOME MEASURE(S) Preg...
متن کاملPreimplantation genetic diagnosis of chromosome balance in embryos from a patient with a balanced reciprocal translocation.
Duplications or deletions are present in a high percentage of the gametes produced by individuals carrying balanced translocations. Preimplantation genetic diagnosis was used to examine chromosome balance in embryos from a patient having a reciprocal translocation within the short arms of chromosomes 5 and 8 (46,XX,t(5;8)(p13;p23)). This woman has two sisters with the translocation unbalanced, ...
متن کاملPreimplantation genetic diagnosis: new reproductive options for carriers of haemophilia.
Preimplantation genetic diagnosis for haemophilia offers couples at risk for transmitting the condition the opportunity to embark on a pregnancy knowing that the embryo is unaffected by the disease. The technique aims to increase the range of reproductive options available to these couples and remove the need for invasive prenatal diagnosis and the difficult decision on whether to terminate an ...
متن کاملNeonatal outcome after preimplantation genetic diagnosis.
OBJECTIVE To examine whether embryo biopsy for preimplantation genetic diagnosis (PGD) influences neonatal outcomes. DESIGN Prospective follow-up cohort. SETTING Tertiary university-affiliated medical center. PATIENT(S) 242 children born after PGD, 242 children born after intracytoplasmic sperm injection (ICSI) (158 singletons and 42 twins pairs in each group), and 733 children born after...
متن کاملPreimplantation genetic diagnosis for an insertional translocation carrier.
BACKGROUND While preimplantation genetic diagnosis (PGD) is well established for carriers of reciprocal terminal translocations, reports on PGD for insertional translocation carriers are lacking. Here, we report on the PGD of an insertional translocation carrier with karyotype 46,XX,ins(14;2)(q21;q31q35). Due to the possibility of crossovers within the inserted region, rather than a single prob...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2013
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(13)60116-9